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  1. ; ; ( , Journal of Computing and Information Science in Engineering)
    Abstract Cerebrovascular accidents like a stroke can affect the lower limb as well as upper extremity joints (i.e., shoulder, elbow, or wrist) and hinder the ability to produce necessary torque for activities of daily living. In such cases, muscles’ ability to generate forces reduces, thus affecting the joint’s torque production. Understanding how muscles generate forces is a key element to injury detection. Researchers have developed several computational methods to obtain muscle forces and joint torques. Electromyography (EMG) driven modeling is one of the approaches to estimate muscle forces and obtain joint torques from muscle activity measurements. Musculoskeletal models and EMG-driven models require necessary muscle-specific parameters for the calculation. The focus of this study is to investigate the EMG-driven approach along with an upper extremity musculoskeletal model to determine muscle forces of two major muscle groups, biceps brachii and triceps brachii, consisting of seven muscle-tendon units. Estimated muscle forces are used to determine the elbow joint torque. Experimental EMG signals and motion capture data are collected for a healthy subject. The musculoskeletal model is scaled to match the geometric parameters of the subject. Then, the approach calculates muscle forces and joint moment for two tasks: simple elbow flexion extension and triceps kickback. Individual muscle forces and net joint torques for both tasks are estimated. The study also has compared the effect of muscle-tendon parameters (optimal fiber length and tendon slack length) on the estimated results. 
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    Free, publicly-accessible full text available June 1, 2024
  2. ; ; ; ( , Proceedings of the 7th International Digital Human Modeling Symposium)
    The ability to predict the decline in muscle strength over the course of an activity (i.e., fatigue) can be a crucial aid to task design, injury prevention, and rehabilitation efforts. Current models of muscle fatigue have been hitherto validated only for isometric contractions, but most real-world tasks are dynamic in nature, involving continuously varying joint velocities. It has previously been proposed that a three-compartment-controller (3CC) model might be used to predict fatigue for such tasks by using it in conjunction with joint- and direction-specific torque-velocity-angle (TVA) surfaces. This allows for the calculation of a time-varying target load parameter that can be used by the 3CC model, but it increases model complexity and has not been validated by experimental data. An alternative approach is proposed where the effect of joint velocity is modeled by a velocity parameter and integrated into the fatigue model equations, removing the dependence on external TVA surfaces. The predictions using both methods are contrasted against experimental data collected from 20 subjects in a series of isokinetic tests involving the knee and shoulder joints, covering a range of velocities encountered in day-to-day tasks. A much lower degree of fatigue is observed for moderate velocities compared to that for very low or very high velocities. Predictions using the integrated velocity parameter are computationally less expensive than using TVA surfaces and are also closer to experimentally obtained values. The modified fatigue model can therefore be applied to dynamic tasks with varying velocities when the task is discretized into several isokinetic tasks. 
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  3. ; ; ; ( , ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference)
    Exoskeleton technology has gained great interests in several fields including robotics, medicine, rehabilitation, ergonomics, and military. Especially, upper-limb exoskeletons are developed aiming to increase worker’s physical ability such as stability, force and power production and reduce biomechanical loads, working fatigue, which relieves overexertion risk. Extensive research has been conducted to assess existing and newly proposed exoskeletons, but they still have trade-off and user convenience issues to resolve. Therefore, the primary purpose of this paper is to review classification of the upper-limb exoskeletons and functional assessment, particularly regarding the complex interactions between human and exoskeleton. Secondly the paper is to provide insight in issues associated with the upper-limb exoskeletons. Finally, discussion on future directions for upper limb exoskeleton development and assessment is presented. 
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  4. ; ; ; ( , Journal of Biomechanics)
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  5. ; ; ; ; ( , Proceedings of ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference)
    Abstract

    In this study, a hybrid predictive model is used to predict 3D asymmetric lifting motion and assess potential musculoskeletal lower back injuries for asymmetric lifting tasks. The hybrid model has two modules: a skeletal module and an OpenSim musculoskeletal module. The skeletal module consists of a dynamic joint strength based 40 degrees of freedom spatial skeletal model. The skeletal module can predict the lifting motion, ground reaction forces (GRFs), and center of pressure (COP) trajectory using an inverse dynamics based optimization method. The equations of motion are built by recursive Lagrangian dynamics. The musculoskeletal module consists of a 324-muscle-actuated full-body lumbar spine model. Based on the generated kinematics, GRFs and COP data from the skeletal module, the musculoskeletal module estimates muscle activations using static optimization and joint reaction forces through the joint reaction analysis tool. Muscle activation results between simulated and experimental EMG are compared to validate the model. Finally, potential lower back injuries are evaluated for a specific-weight asymmetric lifting task. The shear and compression spine loads are compared to NIOSH recommended limits. At the beginning of the dynamic lifting process, the simulated compressive spine load beyond the NIOSH action limit but less than the permissible limit. This is due to the fatigue factors considered in NIOSH lifting equation.

     
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  6. ; ; ; ( , Multibody System Dynamics)
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  7. ; ( , PLOS ONE)
    Vernillo, Gianluca (Ed.)
    A previously developed joint-space metabolic energy expenditure (MEE) model includes subject-specific parameters and was validated using level walking gait data. In this work, we determine how well this joint-space model performs during various walking grades (-8%, 0%, and 8%) at 0.8 m·s ⁻ 1 and 1.3 m·s ⁻ 1 using published gait data in the literature. In response to those results, we formulate an optimization problem and solve it through the particle swam method plus fmincon function in MATLAB to identify a new optimal weighting parameter set for each grade that produces more accurate predicted MEE and we compare our new findings with seven other MEE models in the literature. The current study matched the measured MEE the best with the lowest RMSE values for level (0.45 J·kg ⁻ 1 ·m ⁻ 1 ) and downhill (0.82 J·kg ⁻ 1 ·m ⁻ 1 ) walking and the third lowest RMSE value for uphill (1.56 J·kg ⁻ 1 ·m ⁻ 1 ) walking, where another MEE model, Looney et al., had the lowest RMSE for uphill (1.27 J·kg ⁻ 1 ·m ⁻ 1 ) walking. Bland-Altman plots and three independent-samples t-tests show that there was no statistical significant difference between experimentally measured MEE and estimated MEE during the three walking conditions, meaning that the three new optimal weighting parameter sets can be used with 6 degree of freedom (DOF) lower extremity motion data to better estimate whole body MEE in those scenarios. We believe that this work is a step towards identifying a single robust parameter set that allows for accurate estimation of MEE during any task, with the potential to mitigate a limitation of indirect calorimetry requiring lengthy steady state motion. 
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  8. ; ; ; ( , IEEE Transactions on Biomedical Engineering)
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  9. ; ; ; ; ; ; ( , Nicotine & Tobacco Research)
    Abstract Introduction

    Cross-sectional surveys found behavioral heterogeneity among dual users of combustible and electronic cigarettes. Yet, prior classification did not reflect dynamic interactions between cigarette and e-cigarette consumption, which may reveal changes in product-specific dependence. The contexts of dual use that could inform intervention were also understudied.

     Methods

    This study conducted secondary analysis on 13 waves of data from 227 dual users who participated in a 2-year observational study. The k-means method for joint trajectories of cigarette and e-cigarette consumption was adopted to identify the subtypes of dual users. The time-varying effect model was used to characterize the subtype-specific trajectories of cigarette and e-cigarette dependence. The subtypes were also compared in terms of use contexts.

     Results

    The four clusters were identified: light dual users, predominant vapers, heavy dual users, and predominant smokers. Although heavy dual users and predominant smokers both smoked heavily at baseline, by maintaining vaping at the weekly to daily level the heavy dual users were able to considerably reduce cigarette use. Yet, the heavy dual users’ drop in cigarette dependence was not as dramatic as their drop in cigarette consumption. Predominant vapers appeared to engage in substitution, as they decreased their smoking and increased their e-cigarette dependence. They were also more likely to live in environments with smoking restrictions and report that their use of e-cigarettes reduced cigarette craving and smoking frequency.

     Conclusions

    Environmental constraints can drive substitution behavior and the substitution behavior is able to be sustained if people find the substitute to be effective.

     Implications

    This study characterizes subtypes of dual users based on the dynamic interactions between cigarette use and e-cigarette use as well as product-specific trajectories of dependence. The subtypes differ in not only sociodemographic characteristics but also contexts of cigarette and e-cigarette use. Higher motivation to use e-cigarettes to quit smoking and less permissive environment for smoking may promote substitution of cigarettes by e-cigarettes.

     
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  10. ; ; ( , Journal of Biomechanics)
    null (Ed.)
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